Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COGNITIVE DEFICITS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | COGNITIVE DEFICITS |
Knowledge base pages for this entity
graph TD
COGNITIVE_DEFICITS["COGNITIVE DEFICITS"]
microglial_repopulation["microglial repopulation"] -->|"treats"| COGNITIVE_DEFICITS
Connexin43_Hemichannel_Blockad["Connexin43 Hemichannel Blockade"] -.protects against.-> COGNITIVE_DEFICITS
Primary_Familial_Brain_Calcifi["Primary Familial Brain Calcification"] -->|"causes"| COGNITIVE_DEFICITS
CHI3L1_Depletion["CHI3L1 Depletion"] -.protects against.-> COGNITIVE_DEFICITS
Diosmin["Diosmin"] -->|"treats"| COGNITIVE_DEFICITS
mAb2A7["mAb2A7"] -->|"treats"| COGNITIVE_DEFICITS
Hemichannel_Blockade["Hemichannel Blockade"] -.protects against.-> COGNITIVE_DEFICITS
CD2AP_Deficiency["CD2AP Deficiency"] -.protects against.-> COGNITIVE_DEFICITS| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| HMGB1 | biomarker_for | protein | 0.95 |
| Dasatinib | treats | drug | 0.92 |
| Quercetin | treats | compound | 0.92 |
| microglial repopulation | treats | phenotype | 0.90 |
| Connexin43 Hemichannel Blockade | protects_against | mechanism | 0.90 |
| Primary Familial Brain Calcification | associated_with | disease | 0.90 |
| Primary Familial Brain Calcification | causes | disease | 0.90 |
| CHI3L1 Depletion | protects_against | mechanism | 0.90 |
| Diosmin | treats | drug | 0.90 |
| mAb2A7 | treats | drug | 0.90 |
| Hemichannel Blockade | protects_against | mechanism | 0.90 |
| Tetrahydroxy Stilbene Glucoside | treats | compound | 0.90 |
| ST8SIA1 | protects_against | gene | 0.90 |
| Mab2A7 | treats | drug | 0.90 |
| BDNF | ameliorates | gene | 0.90 |
| GJA1 | protects_against | protein | 0.90 |
| STING | contributes_to | protein | 0.90 |
| amyloid | causes | compound | 0.90 |
| Mir-532-5P | treats | biomarker | 0.90 |
| ISG15 | causes | gene | 0.90 |
| Cellular Senescence | causes | process | 0.88 |
| CD2AP Deficiency | protects_against | phenotype | 0.87 |
| Amyloidosis | causes | disease | 0.85 |
| CHI3L1/CRTH2/CTNNB1 Cascade | mediates | pathway | 0.85 |
| High Glucocorticoid Levels | associated_with | biomarker | 0.85 |
| GJA1 | associated_with | gene | 0.85 |
| Glucocorticoid Hormones | causes | compound | 0.85 |
| Brain Cholesterol Accumulation | causes | phenotype | 0.85 |
| Neuronal Apoptosis | causes | process | 0.85 |
| GJA1 hemichannel blockade | suppresses | process | 0.85 |
| AKT | protects_against | gene | 0.85 |
| Microglia | involved_in | cell_type | 0.85 |
| p38γ Depletion | causes | mechanism | 0.82 |
| High Glucocorticoid Levels | causes | biomarker | 0.80 |
| C9orf72 repeat expansion | causes | gene | 0.80 |
| DA1 | treats | drug | 0.80 |
| reactive oxygen species | causes | compound | 0.80 |
| CONNEXIN43 | prevents | protein | 0.80 |
| CONNEXIN43 | mitigates | protein | 0.80 |
| Aβ plaque | causes | protein | 0.70 |
| Repetitive TBI | causes | disease | 0.70 |
| TDP-43 | associated_with | protein | 0.70 |
| mitochondrial dysfunction | causes | process | 0.70 |
| inflammation | associated_with | process | 0.70 |
| CHRNA7 | therapeutic_target | gene | 0.60 |
| DMPK | associated_with | gene | 0.60 |
| BDNF | protects_against | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||